Oprah Winfrey plans to dedicate a show investigating abuses at puppy mills to her cocker spaniel, Sophie, who died last month from kidney failure.

“Sophie gave me 13 years of unconditional love. She was a true love in my life,” Winfrey says on the broadcast scheduled to air Friday. (Advance remarks from the show were released Tuesday by Harpo Productions.)

The show features special correspondent Lisa Ling investigating puppy mills, which Ling calls “horrific” and “haunting.”

Winfrey says the show is “for anybody ...